Hydrochlorothiazide successfully normalized blood pressure and electrolytes and resolved periodic paralysis in a pediatric patient with Gordon's syndrome.
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Supports HCTZ in Gordon syndrome with paralysis; single case leaves open need for controlled confirmation.
We present the case of a 14-year-old boy who had secondary hyperkalemic periodic paralysis caused by Gordon's syndrome. This syndrome consists of hypertension, tubular acidosis, and hyperkalemia with normal glomerular filtration rate. The pathophysiological mechanism is still unknown. Pathophysiological studies suggest that in this disorder the kidney lacks sensitivity to atrial natriuretic peptide. After treatment with hydrochlorothiazide, serum potassium and plasma aldosterone values, plasma renin activity, and blood pressure became normal and the attacks of periodic paralysis disappeared.
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Pasman et al. (1989) studied this question.
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