Population
Aortic segments from 6-month-old normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR)
Comparison
Hydrogen peroxide at single or cumulative… vs Endothelium-denuded segments, or segments…
Design
Preclinical
Authors
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Supports investigation of COX-thromboxane pathways in hypertensive vessels; leaves open human translation.
In rat aorta, H2O2 induces contractions mediated by the cyclo-oxygenase pathway (likely thromboxane A2), with endothelial nitric oxide providing a protective role that is lost in hypertension.
Rodríguez-Martínez et al. (1998) studied this question.
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