Why the study?
Does metabolic acid-base disturbance influence hemodynamics differently in normotensive versus hypertensive subjects?
Does metabolic acid-base disturbance influence hemodynamics differently in normotensive versus hypertensive subjects?
Acute metabolic acidosis induced by hydrochloric acid infusion does not significantly alter blood pressure or cardiac output in normotensive or hypertensive subjects, though it may moderately increase peripheral resistance in hypertensives.
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Acute metabolic acidosis appears hemodynamically neutral across groups; leaves open whether modest resistance changes in hypertension warrant targeted study.
Noboru Takekoshi (1968) studied this question.
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