Why the study?
Does hypoxia and/or hypercapnic acidosis reduce the toxic dose of acetylstrophanthidin required to produce arrhythmias in anesthetized dogs?
Population
38 anesthetized mongrel dogs weighing 14-25 kg
Comparison
Acetylstrophanthidin 5 mcg/kg/min IV infusion… vs Acetylstrophanthidin 5 mcg/kg/min IV infusion…
Design
Preclinical, In consecutive animals, the order of study was reversed
Follow-up
24 hours between study periods
Authors
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Combined hypoxia-acidosis lowers acetylstrophanthidin arrhythmia threshold in dogs; leaves open relevance to human digitalis dosing.
Does hypoxia and/or hypercapnic acidosis reduce the toxic dose of acetylstrophanthidin required to produce arrhythmias in anesthetized dogs?
Acute hypoxia, but not hypercapnic acidosis alone, significantly increases the sensitivity of the heart to acetylstrophanthidin-induced arrhythmias, primarily via reflexly augmented sympathetic stimulation.
Williams et al. (1968) studied this question.
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