Why the study?
The study evaluated the impact of different durations of a biphasic rectangular pulse on the efficiency of defibrillation using mathematical modeling of a cardiomyocyte.
Mathematical modeling of a guinea pig cardiomyocyte demonstrates that a biphasic rectangular defibrillating pulse of 4 ms duration provides optimal efficiency.
Cardiomyocyte modeling suggests duration-dependent defibrillation efficiency; leaves open translation to clinical devices or in vivo settings.
The paper presents the results of our research study on the impact of different durations of a biphasic rectangular pulse on the efficiency of the defibrillating action based on modeling and simulation of a cardiomyocyte in the framework of Cell Electrophysiology Simulation Environment. We used Luo-Rudy Mammalian Ventricular Model II (dynamic) as the mathematical model of the biochemical processes, which occur both on the surface and inside a cardiomyocyte in a guinea pig. An analysis of the obtained results allowed us to determine the optimal time of the defibrillating pulse. It has been shown that a pulse of 4 ms duration has the highest efficiency. The research has been carried out directly based on the mathematical model and simulation of the cardiomyocyte that makes it possible to minimize errors which may occur in experiments on animals
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Чернов et al. (2021) studied this question.
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