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July 1, 1983IEEE Transactions on Biomedical Engineering

Transthoracic Ventricular Defibrillation in the 100 kg Calf with Symmetrical One-Cycle Bidirectional Rectangular Wave Stimuli

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Why the study?

Do symmetrical one-cycle bidirectional rectangular-wave shocks improve defibrillation success compared to unidirectional shocks in a 100 kg calf model?

Population

47 calves weighing approximately 100 kg undergoing induced ventricular fibrillation of 30 s duration.

Comparison

Symmetrical one-cycle bidirectional… vs Unidirectional rectangular wave shocks.

Design

Preclinical

Authors

JSJohn C. SchuderUniversity of Missouri Health SystemJGJerry H. GoldUniversity of MissouriHSHarry StoeckleUniversity of Missouri Health System

Discussion

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Overview

Should not change clinical defibrillation practice; leaves open translation of bidirectional rectangular waves to human use.

Structured PICO

Do symmetrical one-cycle bidirectional rectangular-wave shocks improve defibrillation success compared to unidirectional shocks in a 100 kg calf model?

P
Population
47 calves weighing approximately 100 kg (39 in primary study, 8 in supplementary study weighing 91-110 kg) undergoing induced ventricular fibrillation of 30 s duration.
I
Intervention
Symmetrical one-cycle bidirectional rectangular-wave shocks (pulse widths 0.5-64 ms, amplitudes 35-140 A, energies 93-1567 J; specifically 50 A, 10 ms in supplementary study).
C
Comparator
Unidirectional rectangular wave shocks (70 A, 6 ms in supplementary study, plus historical data).
O
Outcome
Percent successful defibrillation of ventricular fibrillation of 30 s duration.

Bidirectional rectangular wave shocks provide higher first-shock defibrillation success rates and broader effective parameter ranges than unidirectional shocks in a large animal model.

Cite This Study

Schuder et al. (1983) studied this question.

synapsesocial.com/papers/6a726344e5469ee92be263a2https://doi.org/10.1109/tbme.1983.325042
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Transthoracic ventricular defibrillation in the 100 kg calf with unidirectional rectangular pulses.1977 · 53 citations
  2. 2Transthoracic Ventricular Defibrillation in the 100 kg Calf with Untruncated and Truncated Exponential Stimuli1980 · 70 citations
  3. 3Scaling current and energy with body weight: requirements for the transthoracic ventricular defibrillation of calves as they grow from 50 to 150 kg.1979 · 18 citations
  4. 4Transthoracic Ventricular Defibrillation with Square-wave Stimuli: One-Half Cycle, One Cycle, and Multicycle Waveforms1964 · 63 citations
  5. 5Response of cultured myocardial cells to countershock-type electric field stimulation1978 · 150 citations