Why the study?
Does isolated mitral regurgitation cause anterior mitral leaflet remodeling in an ovine model?
Population
29 sheep (ovine model)
Comparison
Creation of 'pure' mitral regurgitation by… vs Control group
Design
Preclinical, randomized
Follow-up
12 weeks
Authors
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Isolated MR induces anterior mitral leaflet remodeling in ovine model; hypothesis-generating for human valve matrix turnover.
Does isolated mitral regurgitation cause anterior mitral leaflet remodeling in an ovine model?
Isolated mitral regurgitation alone is sufficient to stimulate active matrix turnover and remodeling of the anterior mitral leaflet in an ovine model.
Stephens et al. (2008) studied this question.
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