Key result
Secondary mitral regurgitation shifts leaflet anisotropy with marked circumferential softening and radial stiffening.
Why the study?
Left ventricular remodeling alters mitral valve mechanical stress and leads to active remodeling of the mitral valve, but the mechanical property changes are not well characterized.
Does secondary mitral regurgitation alter the mechanical properties of human mitral valves compared to healthy controls?
Observational (n=18)
Does secondary mitral regurgitation alter the mechanical properties of human mitral valves compared to healthy controls?
p-value: p=<0.01
Secondary mitral regurgitation induces active remodeling of the mitral valve, altering its mechanical properties, which is critical for accurate computational modeling.
Altered anisotropy in this animal model of secondary MR suggests active remodeling; leaves open human translation and supports refined computational models.
Secondary mitral regurgitation occurs when a left ventricular problem causes leaking of the mitral valve. The altered left ventricular geometry changes the orientation of the subvalvular apparatus, thereby affecting the mechanical stress on the mitral valve. This in turn leads to active remodeling of the mitral valve, in order to compensate for the ventricular remodeling. In this study, a biomechanical analysis was performed on eight human mitral valves with secondary mitral regurgitation and ten healthy human mitral valves to better understand this pathophysiology and its effect on the mechanical properties of these tissues. Samples were obtained from the anterior and posterior leaflet and used for planar biaxial mechanical experiments. Uniaxial experiments were performed on four groups of mitral valve chords: anterior basal, anterior marginal, posterior basal and posterior marginal chords. The mechanical response of the mitral valve leaflets was fitted to the May-Newman and Yin constitutive model, whereas the material parameters of the third order Ogden model were determined for the chord samples. Next, stiffnesses calculated at low and high stress levels were statistically analyzed. Leaflet samples with secondary mitral regurgitation showed a small thickness increase and a change in anisotropy index compared to healthy control valves. Diseased leaflets were more compliant circumferentially and stiffer radially, resulting in anisotropic samples with the radial direction being stiffest. In addition, chord samples were slightly thicker and less stiff at high stress in secondary mitral regurgitation, when grouped per leaflet type and insertion region. These results confirm mechanical alterations due to the pathophysiological valvular changes caused by left ventricular remodeling. It is important that these changes in mechanical behavior are incorporated into computational models of the mitral valve.
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Vandemaele et al. (2022) conducted an observational in Secondary mitral regurgitation (n=18). Secondary mitral regurgitation (left ventricular remodeling) vs. Healthy control mitral valves was evaluated on Anisotropy index and stiffness of mitral valve leaflets (p=<0.01). Mitral valve leaflets with secondary mitral regurgitation were more compliant circumferentially and stiffer radially compared to healthy controls, resulting in a significant shift in anisotropy.
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