Why the study?
Does the expression and activity of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) correlate with myxomatous changes in cardiac floppy valves?
Does the expression and activity of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) correlate with myxomatous changes in cardiac floppy valves?
An imbalance between MMPs and TIMPs, along with increased MMP-2 and MMP-9 activity, is associated with myxomatous changes in cardiac floppy valves.
No takes yet. Share an insight, caveat, or question.
Implicates MMP/TIMP imbalance in myxomatous valve degeneration; hypothesis-generating and leaves open any therapeutic role.
Togashi et al. (2007) studied this question.