Extracellular matrix remodelling in human aortic valve disease: the role of matrix metalloproteinases and their tissue inhibitors
Key result
Pathological aortic valves exhibited a four- to seven-fold increase in TIMP-1 compared to controls, with increased MMP-9 and MMP-3 in aortic stenosis indicating an inflammatory state.
Authors
Discussion
Loading...
Member takes
Implication
May indicate inflammatory remodeling in aortic stenosis; hypothesis-generating and requires prospective validation before clinical consideration.
Study Design
Type
Observational (n=80)
PICO
P
Population
Aortic valve disease (n=80)
O
Primary Outcome
Extracellular matrix remodelling and MMP/TIMP levels
Cite This Study
Fondard et al. (2005) conducted an observational in Aortic valve disease (n=80). Pathological aortic valves exhibited a four- to seven-fold increase in TIMP-1 compared to controls, with increased MMP-9 and MMP-3 in aortic stenosis indicating an inflammatory state.