Key result
Type of left ventricular hypertrophy correlated with serum MMP-9 and TIMP-1 levels, showing increased MMP/TIMP ratio in volume load and MMP blockade in pressure load.
Observational
The balance of MMP-9 and TIMP-1 differs between volume and pressure overload in valvular disease, reflecting distinct mechanisms of left ventricular remodeling and fibrosis.
No immediate change to valvular LVH management; leaves open whether MMP/TIMP modulation alters remodeling outcomes.
The study objective was to investigate serum concentrations of matrix metalloproteinase-9 (MMP-9) and it inhibitor (TIMP-1) in patients with aortic stenosis and mitral or aortic regurgitation. It was revealed that serum MMP-9 and TIMP-1 levels correlated with type of left ventricular hypertrophy. In patient with mitral or aortic regurgitation (volume load) MMP/TIMP ratio was increased due to prevalence of MMP-9. Increased serum ММР-9/TIMP-1 index was related to enlargement of left ventricular end-diastolic volume. The greatest disbalance in matrix metalloproteinase system was observed in patients with inherent connective tissue disease. In patients with pressure load hypertrophy (aortic stenosis) serum MMP blockade prevalence was observed, which promoted heart fibrosis development. Furthermore, increased serum TIMP-1 level was associated with decreased left ventricular injection fraction in patients with aortic stenosis.
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Гончарова et al. (2007) conducted an observational in Valvular disease (aortic stenosis, mitral or aortic regurgitation). Type of left ventricular hypertrophy (volume vs pressure load) was evaluated on Serum concentrations of MMP-9 and TIMP-1. Type of left ventricular hypertrophy correlated with serum MMP-9 and TIMP-1 levels, showing increased MMP/TIMP ratio in volume load and MMP blockade in pressure load.
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