Endogenous angiotensin II does not cause noradrenaline supersensitivity in the mesenteric vasculature of renal/salt hypertensive rats, although dietary salt loading slightly increases sensitivity.
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Endogenous angiotensin II does not mediate noradrenaline supersensitivity in renal hypertensive rats; leaves open salt-related mechanisms and precludes clinical translation.
Exogenous angiotensin II causes noradrenaline supersensitivity in rat mesenteric vasculature preparations. The noradrenaline supersensitivity of tissues from renal/salt hypertensive rats, with low plasma renin activity, is not caused by endogenous angiotensin II since it was unaffected by Sar1 Ileu8 angiotensin II. Dietary salt-loading caused a small increase in noradrenaline sensitivity.
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Collis et al. (1976) studied this question.
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