Why the study?
Does infusion of 1 g of aminophylline improve hemodynamic and respiratory parameters in patients with cor pulmonale due to chronic obstructive pulmonary disease?
Population
9 patients with cor pulmonale due to chronic obstructive pulmonary disease
Comparison
Infusion of 1 g of aminophylline vs Control period (baseline before infusion)
Design
Case_series
Authors
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May reduce pressures in cor pulmonale; hypothesis-generating and should not yet change practice.
Does infusion of 1 g of aminophylline improve hemodynamic and respiratory parameters in patients with cor pulmonale due to chronic obstructive pulmonary disease?
Aminophylline infusion significantly reduces pulmonary artery and ventricular end-diastolic pressures in patients with cor pulmonale due to COPD, likely via pulmonary arteriolar dilatation.
Parker et al. (1966) studied this question.
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