Why the study?
Does remoxipride improve behavioural disturbances and psychotic symptoms in elderly patients with dementia or delirium?
Does remoxipride improve behavioural disturbances and psychotic symptoms in elderly patients with dementia or delirium?
Remoxipride showed good clinical efficacy for behavioural disturbances and psychotic symptoms in elderly patients with dementia or delirium, with a low incidence of extrapyramidal symptoms.
Hypothesis-generating for remoxipride in dementia-related behavioral symptoms; prospective randomized trials needed before clinical adoption.
The present study is a retrospective study of remoxipride therapy. A total of 103 patients, 65 years or older, with a DSM-III-R diagnosis of dementia or delirium, were included. They had all been treated with remoxipride because of psychotic symptoms or behavioural disturbances. The dose range of remoxipride was 50-300 mg, the median dose being 75 mg. The clinical effect was rated as good in two thirds of the patients, and side-effects were noted in one fourth. When psychomotor hyperactivity was the dominating problem, a good effect was rated in 81% of the patients. Side-effects were few and mild, the most common being tiredness; only 5 patients showed extrapyramidal symptoms.
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Robertsson et al. (1996) studied this question.
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