What question did this study set out to answer?

To determine whether carotid artery intima-medial thickness increases linearly with advancing age and whether cardiovascular disease or risk factors alter this trajectory.

May 1, 2018Clinical CardiologyOpen Access

Relation between age and carotid artery intima‐medial thickness: a systematic review

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Why the study?

Does the increase in carotid artery intima-medial thickness (cIMT) follow a linear relationship with age, and is it affected by cardiovascular disease or risk factors?

Population

17 studies with 32 unique study populations involving 10,124 healthy individuals free from CVD risk factors…

Comparison

Age (observational exposure) vs null

Design

Systematic_review

Authors

IMInge van den MunckhofRadboud University Nijmegen HJHelen JonesCincinnati Children's Hospital Medical Center MHMaria T. E. HopmanPreventive Cardiology

Discussion

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Implication

Linear cIMT rise with age persists independent of CVD; leaves open whether nonlinearity emerges in diseased cohorts or refines event prediction.

Key Points

To determine whether carotid artery intima-medial thickness increases linearly with advancing age and whether cardiovascular disease or risk factors alter this trajectory.
Searched PubMed, Scopus, and Web of Science for studies evaluating carotid artery intima-medial thickness (cIMT) in healthy cohorts and the general population.
Identified 17 studies (32 unique populations, N=10,124) of healthy individuals without cardiovascular risk factors and 58 studies (115 unique populations, N=65,774) from the general population.
Demonstrated a strong, gradual linear relationship between advancing age and cIMT across age decades in healthy populations (r = 0.91, P < 0.001).
Observed higher overall cIMT in populations with cardiovascular disease, though the linear relationship between age and cIMT remained consistent and was not modified by disease presence or risk factors.

Structured PICO

Does the increase in carotid artery intima-medial thickness (cIMT) follow a linear relationship with age, and is it affected by cardiovascular disease or risk factors?

Population

17 studies with 32 unique study populations involving 10,124 healthy individuals free from CVD risk factors, and 58 studies with 115 unique study populations involving 65,774 individuals from the general population (with and without CVD risk factors).

Intervention

Age (observational exposure)

Comparator

null

Outcome

Relationship between age and carotid artery intima-medial thickness (cIMT)surrogate

Carotid artery intima-medial thickness increases linearly with age, and this relationship is not altered by the presence of cardiovascular disease or its risk factors.

Cite This Study

Munckhof et al. (2018) studied this question.

synapsesocial.com/papers/6a726d78febe604dd70a985d https://doi.org/10.1002/clc.22934

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Implication

Linear cIMT rise with age persists independent of CVD; leaves open whether nonlinearity emerges in diseased cohorts or refines event prediction.

Relation between age and carotid artery intima‐medial thickness: a systematic review

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Relation between age and carotid artery intima‐medial thickness: a systematic review

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider