Why the study?
Observational studies suggested CAD increases the risk of COVID-19 susceptibility and severity, but whether this association is causal remained unclear.
Does genetically predicted coronary artery disease increase the risk of COVID-19 susceptibility?
Does genetically predicted coronary artery disease increase the risk of COVID-19 susceptibility?
Genetically predicted coronary artery disease is causally associated with an increased risk of COVID-19 susceptibility.
Supports causal CAD-COVID-19 link via MR; hypothesis-generating and should not yet change practice.
Observational studies have suggested that having coronary artery disease increases the risk of Coronavirus disease 2019 (COVID-19) susceptibility and severity, but it remains unclear if this association is causal. Inferring causation is critical to facilitate the development of appropriate policies and/or individual decisions to reduce the incidence and burden of COVID-19. We applied Two-sample Mendelian randomization analysis and found that genetically predicted CAD was significantly associated with higher risk of COVID-19: the odds ratio was 1.29 (95% confidence interval 1.11 to 1.49; P = 0.001) per unit higher log odds of having CAD.
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Wu et al. (2020) studied this question.
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