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March 31, 2004AJP Renal Physiology

Increased blood pressure in transgenic mice expressing both human renin and angiotensinogen in the renal proximal tubule

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Why the study?

Does the dual production of human renin and angiotensinogen in the renal proximal tubule increase systemic arterial blood pressure in transgenic mice?

Population

Double-transgenic female mice expressing human renin and human angiotensinogen under the control of the…

Comparison

Testosterone treatment for 2 weeks to induce… vs Testosterone-treated control littermates and…

Design

Preclinical

Follow-up

2 weeks

Authors

JLJulie L. LavoieCentre Hospitalier de l’Université de MontréalKLKristy D. Lake-BruseUniversity of IowaCSCurt D. SigmundVascular Medicine

Discussion

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Implication

Testosterone raises MAP in double-transgenic mice; leaves open whether proximal-tubule RAS regulates blood pressure in humans.

Structured PICO

Does the dual production of human renin and angiotensinogen in the renal proximal tubule increase systemic arterial blood pressure in transgenic mice?

P
Population
Double-transgenic female mice expressing human renin (hREN) and human angiotensinogen (hAGT) under the control of the kidney androgen-regulated promoter (KAP) in the renal proximal tubule (n=8), and control littermates.
I
Intervention
Testosterone treatment for 2 weeks to induce transgene expression.
C
Comparator
Testosterone-treated control littermates and baseline measurements prior to testosterone treatment.
O
Outcome
Mean arterial blood pressure (MAP) measured in the carotid artery using radiotelemetry.surrogate

Dual production of renin and angiotensinogen in the renal proximal tubule results in a systemic increase in arterial pressure, supporting the role of a tissue-specific renin-angiotensin system in blood pressure regulation.

Cite This Study

Lavoie et al. (2004) studied this question.

synapsesocial.com/papers/6a726e9a26a7f98052de4addhttps://doi.org/10.1152/ajprenal.00402.2003
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Proximal tubular fluid, kidney, and plasma levels of angiotensin II in hypertensive ren-2 transgenic rats1997 · 81 citations
  2. 2Renin and angiotensinogen gene expression and intrarenal renin distribution during ACE inhibition1988 · 171 citations
  3. 3Distinct Renin Isoforms Generated by Tissue-Specific Transcription Initiation and Alternative Splicing1999 · 132 citations
  4. 4Novel mechanism of hypertension revealed by cell-specific targeting of human angiotensinogen in transgenic mice1999 · 133 citations
  5. 5Renin expression in renal proximal tubule.1993 · 165 citations