What question did this study set out to answer?

To investigate the relationships between plasma levels of coagulation factor XIII subunits, FXIII cross-linking activity, and cardiovascular risk factors such as age, sex, smoking, and hypertension.

August 1, 1999Arteriosclerosis Thrombosis and Vascular Biology

Subunit Antigen and Activity Levels of Blood Coagulation Factor XIII in Healthy Individuals

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Authors

RARobert A.S. AriënsUniversity of Leeds HKH KöhlerUniversidad de Santiago de Chile MMMichael MansfieldLeeds Teaching Hospitals NHS Trust

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Implication

Cross-sectional analysis reveals elevated FXIII levels in females, older individuals, and smokers, indicating potential links to vascular disease pathogenesis.

Key Points

To investigate the relationships between plasma levels of coagulation factor XIII subunits, FXIII cross-linking activity, and cardiovascular risk factors such as age, sex, smoking, and hypertension.
Measured plasma levels of FXIII A-subunit antigen, FXIII B-subunit antigen, and FXIII cross-linking activity in 612 healthy individuals (250 men and 362 women).
Analyzed correlations with age, sex, smoking status, hypertension, and fibrinogen levels using correlation coefficients and multiple regression models.
FXIII A-subunit levels were significantly higher in women than men (111.8% vs. 105.2%, P < 0.01), in smokers vs. non-smokers (117.0% vs. 104.6%, P < 0.0005), and in subjects with hypertension (114.9% vs. 107.8%, P < 0.05).
Multiple regression demonstrated that FXIII A-subunit independently increased with female sex (+6.4%, P < 0.007), smoking (+12.3%, P < 0.0005), and age (+3.7% per 10 years, P < 0.0005).
FXIII B-subunit was significantly correlated with FXIII A-subunit (r = 0.60, P < 0.0005) and fibrinogen (r = 0.26, P < 0.0005), while FXIII activity correlated with FXIII A-subunit (r = 0.14, P < 0.0005) and fibrinogen (r = 0.14, P = 0.001).

Cite This Study

Ariëns et al. (1999) studied this question.

synapsesocial.com/papers/6a726f1035aa2c282ce33fd4 https://doi.org/10.1161/01.atv.19.8.2012

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Implication

Cross-sectional analysis reveals elevated FXIII levels in females, older individuals, and smokers, indicating potential links to vascular disease pathogenesis.

Subunit Antigen and Activity Levels of Blood Coagulation Factor XIII in Healthy Individuals

Discussion

Member takes

Implication

Key Points

Cite This Study

Subunit Antigen and Activity Levels of Blood Coagulation Factor XIII in Healthy Individuals

Discussion

Member takes

Implication

Key Points

Cite This Study

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