Why the study?
Does phosphorylation of the 20,000 dalton myosin light chain permit actin-activation of uterine smooth muscle myosin?
Population
Myosin purified from ovine uterine smooth muscle
Comparison
Phosphorylation of the 20,000 dalton myosin… vs Unphosphorylated myosin / absence of actin
Design
Preclinical
Authors
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Hypothesis-generating for uterine smooth muscle regulation; leaves open translation to human contractility disorders.
Does phosphorylation of the 20,000 dalton myosin light chain permit actin-activation of uterine smooth muscle myosin?
This basic science study demonstrates that phosphorylation of the 20,000 dalton myosin light chain is essential for actin-activation of uterine smooth muscle myosin.
Lebowitz et al. (1979) studied this question.
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