Why the study?
Does the 1-step PiCT assay accurately monitor the effects of direct FXa-inhibitors compared to the 2-step method in human blood samples?
Does the 1-step PiCT assay accurately monitor the effects of direct FXa-inhibitors compared to the 2-step method in human blood samples?
The 1-step PiCT assay without pre-incubation is suitable for monitoring the anticoagulant effects of new direct selective FXa-inhibitors, whereas the 2-step method is not.
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1-step PiCT detects direct FXa-inhibitor effects in animal models where 2-step does not; leaves open human monitoring utility pending clinical studies.
Graff et al. (2007) studied this question.
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