The PiCT assay requires different formats (with vs without preincubation) to accurately evaluate irreversible (fondaparinux) versus reversible (rivaroxaban) factor Xa inhibitors in vitro.
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PiCT assay formats must be drug-specific for accurate factor Xa inhibitor testing; leaves open optimal protocols for clinical coagulation monitoring.
Kluft et al. (2012) studied this question.
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