Why the study?
Does combination treatment with sildenafil and beraprost prevent right ventricular arrhythmogenesis and electrical remodeling in a rat model of severe pulmonary hypertension?
Population
Monocrotaline (MCT)-induced rat pulmonary hypertension model (rats injected with MCT 60 mg/kg)
Comparison
Combination treatment with sildenafil and… vs Untreated MCT-induced pulmonary hypertension rats
Design
Preclinical
Follow-up
5 weeks
Authors
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Combination sildenafil-beraprost suppressed PH-induced RV electrical remodeling and arrhythmias in rats; hypothesis-generating for human translation.
Does combination treatment with sildenafil and beraprost prevent right ventricular arrhythmogenesis and electrical remodeling in a rat model of severe pulmonary hypertension?
In a rat model of pulmonary hypertension, right ventricular electrical remodeling and arrhythmogenesis are driven by severe PH and can be prevented by treatment with sildenafil and beraprost.
Tanaka et al. (2013) studied this question.
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