What question did this study set out to answer?

To determine and compare the concentration-dependent effects of halothane, isoflurane, and desflurane on atrial and atrioventricular nodal electrophysiological properties.

August 1, 1998AnesthesiologyOpen Access

Effects of Volatile Anesthetics on Atrial and AV Nodal Electrophysiological Properties in Guinea Pig Isolated Perfused Heart

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Why the study?

Do volatile anesthetics (halothane, isoflurane, desflurane) alter atrial and AV nodal electrophysiological properties in guinea pig isolated perfused hearts?

Population

Guinea pig Langendorff-perfused hearts

Comparison

Volatile anesthetics at 0-2 minimum alveolar… vs Baseline and comparison between different…

Design

Preclinical

Authors

PRPekka RaatikainenElectrophysiology MTMark F. TrankinaMayo Clinic TMTimothy E. MoreyUniversity of Florida

Discussion

Member takes

Implication

May inform volatile selection in arrhythmia-prone patients; leaves open translation to human dysrhythmia risk.

Key Points

To determine and compare the concentration-dependent effects of halothane, isoflurane, and desflurane on atrial and atrioventricular nodal electrophysiological properties.
Evaluated halothane, isoflurane, and desflurane at concentrations of 0 to 2 minimum alveolar concentration (MAC) in guinea pig Langendorff-perfused isolated hearts.
Simultaneously recorded atrial and AV nodal conduction times, atrial monophasic action potential duration, and refractory periods using programmed electrical stimulation and infrared gas analysis.
Halothane depressed atrial conduction the most at equianesthetic concentrations, whereas desflurane produced the greatest shortening of atrial monophasic action potential duration.
At 2 MAC, desflurane significantly shortened atrial effective refractory periods by 18.1 ± 13.5% and isoflurane prolonged them by 13.2 ± 14.7%, while halothane exerted no significant effect on atrial refractoriness.
Anesthetic potency for prolonging AV nodal conduction time and AV nodal effective refractory period followed the rank order of halothane > desflurane > isoflurane.

Structured PICO

Do volatile anesthetics (halothane, isoflurane, desflurane) alter atrial and AV nodal electrophysiological properties in guinea pig isolated perfused hearts?

Population

Guinea pig Langendorff-perfused hearts

Intervention

Volatile anesthetics (halothane, isoflurane, and desflurane) at 0-2 minimum alveolar concentration (MAC)

Comparator

Baseline (0 MAC) and comparison between different anesthetics

Outcome

Atrial and AV nodal conduction times, atrial monophasic action potential duration, and atrial and AV nodal effective refractory periodssurrogate

Volatile anesthetics have distinct concentration-dependent effects on atrial and AV nodal electrophysiology, suggesting different modulatory roles in atrial dysrhythmogenesis.

Cite This Study

Raatikainen et al. (1998) studied this question.

synapsesocial.com/papers/6a7271ebfebe604dd70a9bab https://doi.org/10.1097/00000542-199808000-00020

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Effects of Volatile Anesthetics on Atrial and AV Nodal Electrophysiological Properties in Guinea Pig Isolated Perfused Heart

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Effects of Volatile Anesthetics on Atrial and AV Nodal Electrophysiological Properties in Guinea Pig Isolated Perfused Heart

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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