Why the study?
Do halothane and enflurane alter ventricular conduction, refractoriness, and wavelength in isolated rabbit hearts?
Population
30 isolated rabbit hearts (10 intact, 20 with thin epicardial layer)
Design
Preclinical
Authors
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Does not support practice changes in anesthetic selection; leaves open translation of conduction slowing to human arrhythmia risk.
Do halothane and enflurane alter ventricular conduction, refractoriness, and wavelength in isolated rabbit hearts?
Halothane and enflurane exert only slight ventricular electrophysiologic effects in isolated rabbit hearts, suggesting they do not inherently induce functional conduction block or reentrant arrhythmias.
Aya et al. (1999) studied this question.
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