Why the study?
Is shear-induced platelet aggregation increased in cerebral ischemia and how is it affected by antiplatelet agents?
Population
75 patients with cerebral ischemia and 26 control subjects.
Comparison
Measurement of shear-induced platelet… vs Control subjects (for baseline measurements)
Design
Case-control
Authors
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Supports targeting shear-induced aggregation in atherothrombotic stroke; leaves open whether ticlopidine outperforms aspirin in prospective trials.
Is shear-induced platelet aggregation increased in cerebral ischemia and how is it affected by antiplatelet agents?
Shear-induced platelet aggregation is elevated in specific subtypes of cerebral ischemia and is effectively inhibited by ticlopidine but not low-dose aspirin.
Uchiyama et al. (1994) studied this question.
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