Why the study?
The effect of transiently elevated pathological high shear rates caused by vascular stenosis on platelet activation and aggregation function has not been clarified.
Population
Sodium citrate anticoagulated whole blood
Comparison
Pathological high shear rate exposure across varying times vs un-sheared blood with or without antiplatelet inhibitors
Design
In vitro microfluidic study
Key result
Transient pathological high shear rate exposure significantly increased platelet activation and aggregation in a time-dependent manner compared to un-sheared whole blood.
Authors
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Alerts to prothrombotic risk in high-shear settings; leaves open clinical translation pending in vivo studies.
Transient pathological high shear rate exposure induces platelet activation in a time-dependent manner, which can be differentially inhibited by various antiplatelet agents.
Zhang et al. (2023) studied Platelet activation and aggregation under high shear stress. Pathological high shear rate (8302s-1) exposure vs. Un-sheared whole blood (physiological arterial shear rate 1500 s-1) was evaluated on Platelet activation (P-selectin and GP IIb/IIIa expression) and aggregation levels. Transient pathological high shear rate exposure significantly increased platelet activation and aggregation in a time-dependent manner compared to un-sheared whole blood.
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