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January 1, 2003Thrombosis and Haemostasis

Exposure to 100 dyn/cm2 shear stress for <10-20 sec resulted in minimal activation and rapid disaggregation, whereas exposure >20 sec caused irreversible activation and aggregation.

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Why the study?

Does the duration of exposure to high fluid shear stress affect platelet activation and aggregation?

Population

Platelets in platelet-rich plasma (PRP), washed platelets, and whole blood

Comparison

High fluid shear stress for varying durations vs Unsheared platelets or different durations of…

Design

Preclinical

Authors

ZJZhang JianningABAngela L. BergeronQYQinghua Yu

Discussion

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Overview

Brief high-shear exposure permits disaggregation; hypothesis-generating for refined shear thresholds, requiring human validation before clinical relevance.

Structured PICO

Does the duration of exposure to high fluid shear stress affect platelet activation and aggregation?

P
Population
Platelets in platelet-rich plasma (PRP), washed platelets, and whole blood
I
Intervention
High fluid shear stress (100 dyn/cm2) for varying durations (<10-20 sec vs >20 sec)
C
Comparator
Unsheared platelets or different durations of shear exposure
O
Outcome
Platelet activation (P-selectin expression, PAC-1 binding) and aggregation/disaggregationsurrogate

Platelets have a higher threshold for shear stress than previously believed, requiring longer exposure durations or synergistic stimuli for irreversible activation.

Cite This Study

Jianning et al. (2003) studied this question.

synapsesocial.com/papers/6a70dca1febe604dd709a1f8https://doi.org/10.1160/th03-03-0145
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Platelet Aggregation and Activation under Complex Patterns of Shear Stress2002 · 82 citations
  2. 2“Shear induced platelet activation” - A critical reappraisal1985 · 66 citations
  3. 3Evaluating the impact of transient shear stress on platelet activation, adhesion, and aggregation with microfluidic chip technique2023 · 18 citations
  4. 4Effect of pathological high shear exposure time on platelet activation and aggregation2023 · 13 citations
  5. 5Quantification of Shear‐Induced Platelet Activation: High Shear Stresses for Short Exposure Time2015 · 88 citations