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October 1, 1985Biorheology

Shear stresses up to 255 N/m2 for milliseconds did not elicit active release of beta-TG beyond passive lysis, and ultrastructural signs of activation were suppressed by ADP-scavengers.

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Why the study?

Does short-acting high shear stress directly induce platelet activation?

Population

Platelets (in vitro model)

Design

Preclinical

Authors

LWL. J. WurzingerRORobert OpitzMWMichael Wolf

Discussion

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Overview

Short high-shear stress does not directly activate platelets; leaves open confirmation in human in vivo models.

Structured PICO

Does short-acting high shear stress directly induce platelet activation?

P
Population
Platelets (in vitro model)
I
Intervention
High shear stress (up to 255 N/m2 for milliseconds)
O
Outcome
Active release of beta-TG and ultrastructural signs of platelet activationsurrogate

Direct shear-induced platelet activation is unlikely and appears mostly secondary to biochemical activation by mediators from passively destroyed platelets.

Cite This Study

Wurzinger et al. (1985) studied this question.

synapsesocial.com/papers/6a7e482ef6941e90164c4787https://doi.org/10.3233/bir-1985-22504
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Duration of exposure to high fluid shear stress is critical in shear-induced platelet activation-aggregation2003 · 63 citations
  2. 2Quantification of Shear‐Induced Platelet Activation: High Shear Stresses for Short Exposure Time2015 · 88 citations
  3. 3Shear stress-induced platelet activation enhances blood coagulation more than adenosine diphosphate-induced activation2025
  4. 4Effect of pathological high shear exposure time on platelet activation and aggregation2023 · 13 citations
  5. 5Platelet Activation via Shear Stress Exposure Induces a Differing Pattern of Biomarkers of Activation versus Biochemical Agonists2020 · 60 citations