Key result
Exposing platelets to a high shear stress of 100 dyn/cm2 for 2.5 seconds followed by low shear induced aggregation with significantly less CD62P expression than ADP treatment.
Population
Platelets (in vitro model of arterial stenosis)
Comparison
Exposure to a shear profile containing both high… vs Platelets treated with ADP
Design
Preclinical
Authors
Loading...
Questions prolonged high-shear in vitro platelet assays for arterial stenosis; leaves open the thrombotic contribution of post-stenotic low flow.
Post-stenosis low flow enhances shear-induced platelet aggregation, which appears to be a mechanical crosslinking process requiring minimal platelet activation.
Zhang et al. (2002) studied this question. Complex pattern of shear stress (high shear followed by low shear) vs. ADP treatment was evaluated on Platelet aggregation and CD62P expression. Exposing platelets to a high shear stress of 100 dyn/cm2 for 2.5 seconds followed by low shear induced aggregation with significantly less CD62P expression than ADP treatment.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: