Key result
High shear stress (10500 s-1) simulating severe stenosis significantly induced platelet activation and microparticle formation in native human blood compared to physiological shear (P<0.008).
Why the study?
Does high shear stress simulating severe arterial stenosis increase platelet activation and microparticle formation in native human blood?
Population
Native nonanticoagulated human blood drawn directly from an antecubital vein
Comparison
Exposure to high wall shear rates simulating… vs Exposure to physiological shear rate or less…
Design
Preclinical
Follow-up
0.075 to 3.045 seconds
Authors
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High shear may promote thrombosis in stenosis; hypothesis-generating for microparticle-targeted therapies.
Does high shear stress simulating severe arterial stenosis increase platelet activation and microparticle formation in native human blood?
p-value: p=< .008
High shear stress simulating severe atherosclerotic arteries significantly activates platelets and triggers microparticle formation, which is potentiated by sudden shear changes and collagen exposure.
Holme et al. (1997) studied None (native human blood). High shear stress (10500 s-1) and severe stenosis vs. Physiological shear (420 s-1) or less severe stenosis (2600 s-1) was evaluated on Platelet activation and microparticle formation (p=< .008). High shear stress (10500 s-1) simulating severe stenosis significantly induced platelet activation and microparticle formation in native human blood compared to physiological shear (P<0.008).
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