Key result
Single-pass short exposure to high shear has no effect on platelet activation markers.
Population
Platelets (in vitro model)
Design
Preclinical
Authors
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Brief high-shear exposure may not activate platelets; leaves open cumulative or prolonged effects in device thrombosis models.
A single pass of platelets through high shear rates for very short exposure times (milliseconds) does not induce significant granule release or receptor shedding in vitro.
Alsmadi et al. (2017) studied Platelet activation under high shear. Transient high shear exposure via constricted microfluidic device was evaluated on Platelet activation (CD62P, PF4, βTG) and receptor shedding (GPVI, GPIb). A single pass to high shear with short exposure times (milliseconds) had no effect on platelet activation markers (CD62P, GPVI, GPIb) or alpha granule release.
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