December 1, 1997AnesthesiologyOpen Access

Conformational State-dependent Effects of Halothane on Cardiac Na sup + Current

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Population

Single, enzymatically isolated guinea pig ventricular myocytes

Comparison

1.2 mM halothane at different holding potentials vs Control conditions (absence of halothane)

Design

Preclinical

Authors

Discussion

Indicates potential for enhanced Na channel block in ischemic tissue; leaves open clinical relevance to halothane arrhythmogenesis.

Population

Single, enzymatically isolated guinea pig ventricular myocytes

Intervention

1.2 mM halothane at different holding potentials (-110, -80, or -65 mV)

Comparator

Control conditions (absence of halothane)

Outcome

Effects on cardiac Na+ current (I(Na)) including peak I(Na) depression, recovery from inactivation, and use-dependent blocksurrogate

Halothane depresses cardiac sodium current in a state-dependent manner, with greater potency when more channels are in the inactivated state.

Weigt et al. (1997) studied this question.

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