Key result
Halothane depressed the plateau and shortened action potentials, and reduced the amplitude of inward calcium currents and contractions in guinea-pig ventricular myocytes.
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May inform mechanisms of halothane cardiotoxicity; leaves open translation to human ventricular function.
Terrar et al. (1988) studied this question. Halothane vs. Verapamil was evaluated on Electrical activity and contraction. Halothane depressed the plateau and shortened action potentials, and reduced the amplitude of inward calcium currents and contractions in guinea-pig ventricular myocytes.
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