Why the study?
Does halothane block electrical coupling in guinea-pig ventricular cell pairs?
Population
Cell pairs isolated from guinea-pig ventricular muscle
Comparison
Halothane (and isoflurane) vs Baseline/control conditions
Design
Preclinical
Authors
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Halothane-induced uncoupling may explain arrhythmogenicity in guinea-pig models; leaves open relevance to human anesthesia.
Does halothane block electrical coupling in guinea-pig ventricular cell pairs?
Halothane induces electrical uncoupling in ventricular cell pairs, providing a potential mechanism for its arrhythmogenic effects.
Terrar et al. (1988) studied this question.
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