March 7, 1989Quarterly Journal of Experimental PhysiologyOpen Access

Influence of Halothane on Contraction at Positive Membrane Potentials in Single Cells Isolated From Guinea‐pig Ventricular Muscle

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Population

Single cells isolated from guinea-pig ventricular muscle

Design

Preclinical

Authors

DTDerek A. TerrarUniversity of Oxford JVJason VictoryNuffield Foundation

Discussion

Member takes

Implication

Halothane's voltage-dependent effects on contraction merit caution in anesthetic contexts; leaves open calcium entry mechanisms for targeted investigation.

Structured PICO

Population

Single cells isolated from guinea-pig ventricular muscle

Intervention

Halothane (2%) and Isoflurane (3.2%) under voltage-clamp conditions

Outcome

Contraction (measured by an optical method) and time-to-peak contraction at various membrane potentialssurrogate

Halothane exerts differential effects on ventricular muscle contraction depending on membrane potential, suggesting varying mechanisms for calcium entry.

Cite This Study

Terrar et al. (1989) studied this question.

synapsesocial.com/papers/6a9140348a938dc457a152ae https://doi.org/10.1113/expphysiol.1989.sp003251

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Implication

Halothane's voltage-dependent effects on contraction merit caution in anesthetic contexts; leaves open calcium entry mechanisms for targeted investigation.

Influence of Halothane on Contraction at Positive Membrane Potentials in Single Cells Isolated From Guinea‐pig Ventricular Muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Influence of Halothane on Contraction at Positive Membrane Potentials in Single Cells Isolated From Guinea‐pig Ventricular Muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider