Population
Single isolated bullfrog atrial cells obtained by enzymatic dissociation
Design
Preclinical
Authors
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Leaves open clinical translation from bullfrog cells; hypothesis-generating for halothane's ionic effects in mammals.
Halothane alters specific transmembrane ionic currents in bullfrog atrial cells, providing a mechanistic basis for its negative inotropic and chronotropic effects.
Hirota et al. (1988) studied this question.
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