July 1, 1994CirculationOpen Access

Impact of age on clinical outcome and postlytic management strategies in patients treated with intravenous thrombolytic therapy. Results from the TIMI II Study. TIMI II Investigators.

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Why the study?

Does an invasive postlytic strategy improve mortality or reinfarction compared to a conservative strategy in patients with acute myocardial infarction treated with thrombolytic therapy across different age groups?

Population

3,339 patients with acute myocardial infarction treated with intravenous recombinant tissue-type plasminogen…

Comparison

Invasive postlytic strategy vs Conservative postlytic strategy

Design

Cohort, Randomly assigned to an invasive or a conservative postlytic strategy

Follow-up

1 year

Authors

FAFrank V. AguirreInterventional / Structural Cardiology RMRobert P. McMahonWesleyan University HMHiltrud MuellerPhilipps University of Marburg

Discussion

Member takes

Implication

No outcome advantage for invasive over conservative post-thrombolysis strategy by age; leaves open applicability to current reperfusion practices.

Structured PICO

Population

3,339 patients with acute myocardial infarction treated with intravenous recombinant tissue-type plasminogen activator (rTPA), heparin, and aspirin, divided into age groups: <50 years (n=841), 50-64 years (n=1,639), and 65-75 years (n=859).

Intervention

Invasive postlytic strategy (routine cardiac catheterization and coronary revascularization)

Comparator

Conservative postlytic strategy

Outcome

1-year mortality and 42-day rates of reinfarction, death, or death or reinfarctionhard clinical

Routine use of cardiac catheterization and coronary revascularization does not improve immediate or 1-year outcomes compared with a conservative strategy in young, middle-aged, or elderly patients after thrombolytic therapy for acute myocardial infarction.

Cite This Study

Aguirre et al. (1994) studied this question.

synapsesocial.com/papers/6a7272fde5469ee92be26b60 https://doi.org/10.1161/01.cir.90.1.78

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Implication

No outcome advantage for invasive over conservative post-thrombolysis strategy by age; leaves open applicability to current reperfusion practices.

Impact of age on clinical outcome and postlytic management strategies in patients treated with intravenous thrombolytic therapy. Results from the TIMI II Study. TIMI II Investigators.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Impact of age on clinical outcome and postlytic management strategies in patients treated with intravenous thrombolytic therapy. Results from the TIMI II Study. TIMI II Investigators.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider