Why the study?
Are serum levels of MDA, vitamin A, and alpha-tocopherol altered in non-alcoholic steatohepatitis and associated with histopathologic severity?
Are serum levels of MDA, vitamin A, and alpha-tocopherol altered in non-alcoholic steatohepatitis and associated with histopathologic severity?
Serum oxidative stress and antioxidant markers are altered in NASH but do not correlate with histopathologic severity.
Oxidative markers differ in NASH without severity correlation; hypothesis-generating and should not yet guide practice.
The aims of our study were to estimate serum levels of malondialdehyde (MDA), serum levels of vitamin A and alpha-tocopherol as antioxidants and determine relationship of these with histopathologic severity in patients with non-alcoholic steatohepatitis (NASH). Twenty-nine patients with biopsy-proven NASH were included to study. NASH were histopathologically scored for grading and staging. Serum MDA and vitamin A levels were increased in patients with NASH and simple steatosis as compared to healthy control group. Serum alpha-tocopherol levels measured in simple steatosis and NASH were significantly lower than in healthy control group. There was no significant difference between grade/stage 0-1 and grade/stage 2-3 in terms of MDA, vitamin A and alpha-tocopherol levels. Serum MDA and vitamin A levels are increased in simple steatosis and NASH. MDA, vitamin A and alpha-tocopherol levels in NASH were not associated with the histopathologic severity.
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Bahçecioğlu et al. (2004) studied this question.
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