Key result
NASH is associated with higher IL-1β and IL-6 levels than NAFL and healthy controls.
Why the study?
Pro-inflammatory cytokines are associated with systemic inflammatory responses, prompting evaluation of circulating IL-1β, IL-6, and TNF-α levels in patients with NAFL and NASH compared to healthy individuals.
Case-Control (n=90)
Pro-inflammatory cytokines IL-1β and IL-6, along with ALT activity, are significantly elevated in patients with NASH compared to those with NAFL or healthy controls.
IL-1β and IL-6 elevations distinguish NASH from NAFL; hypothesis-generating for targeted therapies pending prospective validation.
BACKGROUND: Pro-inflammatory cytokines are associated with systemic inflammatory responses. OBJECTIVE: To investigate the levels of pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α) in patients with non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH) compared to healthy individuals. METHODS: This case-control study was conducted on 30 patients with NAFL, 30 patients with NASH, and 30 healthy volunteers. The plasma level of IL-1β, IL-6, and TNF-α were determined by ELISA, and biochemical parameters were measured using colorimetric methods. RESULTS: IL-1β and IL-6 levels were significantly higher in patients with NASH compared with NAFL and control group. However, TNF-α levels had no significant variations in NAFL and NASH patients compared to the control group (p=0.903 and p=0.960, respectively). CONCLUSION: Results showed that the levels of ALT activity and pro-inflammatory cytokines were higher in patients with NASH compared to control and NAFL subjects; Therefore, steatosis and inflammation develop as a result of excessive pro-inflammatory factors in NASH.
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Hadinia et al. (2019) conducted a case-control in Non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH) (n=90). NASH and NAFL vs. Healthy volunteers was evaluated on Plasma levels of IL-1β, IL-6, and TNF-α. Patients with NASH had significantly higher levels of IL-1β and IL-6 compared to NAFL and healthy controls, while TNF-α levels showed no significant variations (p=0.903 and p=0.960).
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