Why the study?
Does the addition of vitamin E to lifestyle modification improve cytokine profiles and liver enzymes in patients with NASH?
Population
16 patients with biopsy-proven nonalcoholic steatohepatitis (NASH)
Comparison
Step 1 American Heart Association diet plus… vs Step 1 American Heart Association diet plus…
Design
Cohort
Follow-up
12 weeks
Authors
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Lifestyle modifications may improve NASH markers; vitamin E adds no benefit, leaving open need for RCTs.
Does the addition of vitamin E to lifestyle modification improve cytokine profiles and liver enzymes in patients with NASH?
Lifestyle modifications improve liver enzymes and lipid profiles in NASH, but short-term vitamin E supplementation provides no additional benefit on cytokine profiles.
Kugelmas et al. (2003) studied this question.
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