December 1, 1988The Journal of Cell BiologyOpen Access

Ifm(2)2 is a myosin heavy chain allele that disrupts myofibrillar assembly only in the indirect flight muscle of Drosophila melanogaster.

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Population

Drosophila melanogaster flies homozygous for the Ifm(2)2 allele

Design

Preclinical

Authors

CMChun MaFuling Center Hospital of Chongqing SFS FalkenthalThe Ohio State University

Discussion

Member takes

Implication

Provides Drosophila model for myosin heavy chain loss; leaves open relevance to human cardiac myopathies.

Structured PICO

Population

Drosophila melanogaster flies homozygous for the Ifm(2)2 allele

Intervention

Ifm(2)2 mutation (myosin heavy chain allele)

Outcome

Myosin heavy chain mRNA and protein accumulation and thick filament assembly in indirect flight musclesurrogate

The Ifm(2)2 mutation disrupts thick filament assembly specifically in the indirect flight muscle of Drosophila by interfering with myosin heavy chain mRNA or protein accumulation.

Cite This Study

Ma et al. (1988) studied this question.

synapsesocial.com/papers/6a727cf035aa2c282ce34781 https://doi.org/10.1083/jcb.107.6.2613

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Ifm(2)2 is a myosin heavy chain allele that disrupts myofibrillar assembly only in the indirect flight muscle of Drosophila melanogaster.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Ifm(2)2 is a myosin heavy chain allele that disrupts myofibrillar assembly only in the indirect flight muscle of Drosophila melanogaster.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider