Key result
Obesity is reproducibly linked to type 2 diabetes mellitus, modified by lifestyle, duration, and genetics.
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Obesity is a growing epidemic affecting all ages in both industrialized and developing countries. The most common suggested cause of this epidemic is the increasing levels of urbanization and lifestyle changes toward sedentary life and adopting western dietary patterns. The association between obesity and type 2 diabetes mellitus (T2DM) has been reproducibly observed in cross-sectional and prospective studies across various populations, even when using different fatness measures and diagnostic criteria for T2DM. However, there are some modifying factors that make such an association complex and multifactorial. These modifying factors include the duration of obesity, body fat distribution, physical activity, diet, and genetics/ethnicity. This review aims to summarize the evidence of this association and its potential modifying factors.
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Al-Quwaidhi et al. (2013) conducted a review in Obesity and type 2 diabetes mellitus. Obesity was evaluated on Type 2 diabetes mellitus. Obesity is reproducibly associated with type 2 diabetes mellitus across populations, modified by obesity duration, fat distribution, physical activity, diet, and genetics.
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