Key result
Arterial compliance in vivo relies on indirect estimation via pulse wave velocity given methodological limitations.
Why the study?
Arterial compliance in humans has been a somewhat neglected subject in cardiovascular research due to methodological difficulties in studying the viscoelastic properties of the arterial tree in vivo.
Highlights that despite methodological challenges requiring indirect in vivo estimation (such as pulse wave velocity), aberrations in arterial distensibility play an important role in human circulatory pathophysiology and hypertension.
Answers are grounded in this paper and cite their sources.
Indirect arterial compliance estimates warrant cautious clinical interpretation; leaves open need for direct in vivo methods.
Study of the viscoelastic properties of the arterial tree in man i s d i f f i c u l t .Pbst previous reports on a r t e r i a l canpliance ( d i s t e n s i b i l i t y ) in man, i n which canpliance has been estimated d i r e c t l y fran pressure-volme relationships, have involved arteries taken f r m cadavers, ( 1 , 2 ) .In vlvo studies in hmans have usually u t i l i z e d indirect estimates of m p l i a n c e (3-8), such as a r t e r i a l pulse wave velocity (5,B) .Arterial canpliance has been a sanewhat neglected subject i n recent cardiovascular research: t h i s probably r e f l e c t s methalological d i f f i c u l t i e s rather than lack of interest (3-7) and does not imply t h a t aberrations i n a r t e r i a l distens i b i l i t y play no i m p r t a n t role i n human circulatory pathophysiology and disease.
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Randall et al. (1976) conducted a review in Hypertension. Arterial compliance in vivo in humans is typically estimated indirectly (e.g., via pulse wave velocity) due to methodological difficulties, despite its importance in cardiovascular pathophysiology.
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