Why the study?
Does a single acute injection of angiotensin II induce prolonged neuronal and immune system activation in Wistar-Kyoto rats?
Population
80 adult male Wistar-Kyoto (WKY) rats aged 12-14 weeks, weighing 280-320 g.
Comparison
Single acute intra-peritoneal injection of… vs Single intra-peritoneal injection of normal…
Design
Preclinical, Two blinded researchers.
Follow-up
24 hours
Authors
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Acute Ang II may initiate neural-immune memory in animal hypertension models; leaves open relevance to human pathogenesis.
Does a single acute injection of angiotensin II induce prolonged neuronal and immune system activation in Wistar-Kyoto rats?
A single acute hypertensive stimulus with angiotensin II induces prolonged neuro-immune activation that persists long after blood pressure normalizes, suggesting a mechanism for neural sensitization in hypertension.
Zubcevic et al. (2017) studied this question.
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