July 31, 2013PLoS ONEOpen Access

Cardiac Myosin Binding Protein-C Plays No Regulatory Role in Skeletal Muscle Structure and Function

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Structured PICO

Population

6-month-old cMyBP-C null mice (cMyBP-C(t/t)), wild-type (WT) controls, and mdx mice (model of Duchenne muscular dystrophy).

Intervention

Genetic ablation of cardiac myosin binding protein-C (cMyBP-C(t/t) knockout model).

Comparator

Wild-type (WT) control mice.

Outcome

Skeletal muscle structure (histology, ultrastructure), function (twitch tension, tetanic tension, injury susceptibility), and MyBP-C isoform expression.surrogate

Cardiac MyBP-C is dispensable for the development and function of skeletal muscle, with no structural or functional consequences in adult myocytes when ablated.

Discussion

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Implication

No skeletal muscle effects in cMyBP-C knockout mice; confirms cardiac specificity but leaves open human translation.

Cite This Study

Lin et al. (2013) studied this question.

synapsesocial.com/papers/6a727e02febe604dd70aa238 https://doi.org/10.1371/journal.pone.0069671

View Full Paper

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Cardiac Myosin Binding Protein-C Plays No Regulatory Role in Skeletal Muscle Structure and Function

Structured PICO

Discussion

Implication

Cite This Study

Cardiac Myosin Binding Protein-C Plays No Regulatory Role in Skeletal Muscle Structure and Function

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider