June 17, 2003Molecular Biology of the CellOpen Access

A Novel Variant of Cardiac Myosin-binding Protein-C That Is Unable to Assemble into Sarcomeres Is Expressed in the Aged Mouse Atrium

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Population

Aged mouse atria and chicken cardiac myocytes

Design

Preclinical

Authors

NSNaruki SatoBoston University TKTsutomu KawakamiTokai University ANAyako NakayamaMusashino University

Discussion

Member takes

Implication

Hypothesis-generating for age-related atrial remodeling in mice; leaves open any role in human atrial dysfunction.

Structured PICO

Population

Aged mouse atria and chicken cardiac myocytes

Intervention

Expression of a novel alternative spliced form of cardiac MyBP-C, MyBP-C(+)

Outcome

Binding affinity to myosin filaments and connectin/titin, localization to A-bands, and sarcomere structure organizationsurrogate

An age-induced novel isoform of cardiac MyBP-C, MyBP-C(+), disrupts sarcomere assembly and becomes dominant in aged mouse atria, suggesting a mechanism for age-related atrial changes.

Cite This Study

Sato et al. (2003) studied this question.

synapsesocial.com/papers/6a82954f0f52607ca18ada89 https://doi.org/10.1091/mbc.e02-10-0685

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