Why the study?
Does risk factor modification reduce coronary heart disease risk in older adults (aged ≥65 years)?
Does risk factor modification reduce coronary heart disease risk in older adults (aged ≥65 years)?
Risk factor modification in older adults (≥65 years) is as effective in reducing CHD risk as in middle-aged adults, and multivariable risk assessment can help appropriately target interventions.
Supports considering risk factor modification in older adults; leaves open practice change pending randomized trials.
Evidence from epidemiologic studies indicates that the same factors that are associated with increased risk of coronary heart disease (CHD) in middle-aged people are relevant in older adults (i.e., those aged >or=65). The relative risk associated with some risk factors decreases with advancing age but this is offset by greater incidence of CHD among older adults. A growing body of evidence from clinical trials indicates that risk factor modification in older adults reduces CHD risk as effectively as it does in middle-aged adults. Multivariable risk assessment can be used to effectively target intervention to those at significant risk for an initial CHD event and to avoid over-treatment. It is important to appreciate that the average remaining life expectancy after achieving 80 years is about 8 years.
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Kannel et al. (2003) studied this question.
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