Why the study?
Does renal sympathetic denervation reduce blood pressure in patients with persistently uncontrolled hypertension compared to placebo?
Does renal sympathetic denervation reduce blood pressure in patients with persistently uncontrolled hypertension compared to placebo?
This editorial discusses expectations for the Symplicity-HTN 3 trial regarding the blood pressure lowering effect of renal sympathetic denervation versus placebo.
Symplicity-HTN 3 expectations stress placebo-controlled rigor; leaves open renal denervation's BP effect in resistant hypertension.
More than 10% of patients treated for hypertension have persistently uncontrolled blood pressure (BP) despite prescription of antihypertensive drugs (1). Renal sympathetic denervation is an old con...
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Kjeldsen et al. (2013) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: