Why the study?
Do AT1 angiotensin II receptor antagonists reduce the sympathetic response to a cold pressor test in normotensive healthy volunteers?
Do AT1 angiotensin II receptor antagonists reduce the sympathetic response to a cold pressor test in normotensive healthy volunteers?
Short-term administration of AT1 receptor antagonists blunts the blood pressure response to cold stress, demonstrating that endogenous angiotensin II supports sympathetic-mediated stress responses in humans.
AT1 antagonists blunt sympathetic BP surges to cold stress in healthy volunteers; confirms endogenous angiotensin II augments human sympathetic pressor responses.
The aim of this study was to evaluate the effect of short-term administration of AT(1) angiotensin II receptor antagonists on the sympathetic response to a cold pressor test (CPT) in normotensive healthy volunteers. Eighty-two healthy volunteers were included in this double-blind placebo-controlled study. Blood pressure and heart rate were determined before and 175 minutes after oral administration of placebo, losartan (50 mg), valsartan (80 mg), or eprosartan (600 mg). Immediately, the subjects underwent a CPT and then the same hemodynamic parameters were measured. CPT increased arterial blood pressure (systolic, diastolic, and mean) and heart rate in the placebo-treated group. Pretreatment with a single dose of losartan, valsartan, or eprosartan blunted CPT-induced pressor response but not heart rate increase. Our results demonstrate that endogenous angiotensin II, through stimulation of AT(1) receptor, supports sympathetic-mediated stress response in humans.
No takes yet. Share an insight, caveat, or question.
Israel et al. (2007) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: