Why the study?
Does essential hypertension alter the ventilatory response to hypoxia across different age groups?
Does essential hypertension alter the ventilatory response to hypoxia across different age groups?
Augmented hypoxic ventilatory sensitivity is present in early essential hypertension and in descendants with a family history, but this response attenuates with age.
36 patients with essential hypertension and 15 of their adult descendants were investigated and compared with age-matched control groups of 33 and 15 healthy subjects, respectively. The ventilatory response to oxygen breathing and to progressive normo- und isocapnic hypoxia were studied. The reduction of ventilation during hyperoxia was significantly greater in all hypertensive patients. An augmented ventilatory response to hypoxia was found in 20- to 40-year-old patients whereas the older patients (41-60 years) were not different from the age-matched control subjects. Our results indicate that the augmented hypoxic sensitivity in early hypertension, as found also in the young adult descendants with family background of hypertension, is attenuated with age, similar to the normotensive subjects.
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Tafil‐Klawe et al. (2009) studied this question.
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